ankylosingspondylitis

What is ankylosing spondylitis?


Ankylosing spondylitis has no known specific cause, though genetic factors seem to be involved. In particular, people who have a gene called HLA-B27 are at significantly increased risk of developing ankylosing spondylitis.

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Also known as spondylitis, ankylosing, Bechterew Disease, Rheumatoid Spondylitis, spondylarthropathy, Ankylosing Spondylarthritis, Bechterew's Disease, Marie Struempell Disease, Marie-Struempell Disease, seronegative bundle arthropathy, Ankylosing Spondyloarthritis, Bechterews Disease, Spondylarthritis Ankylopoietica, Ankylosing Spondylarthritides, Ankylosing Spondyloarthritides
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Rheumatoid spondylitis

Ankylosing spondylitis is a type of arthritis of the spine. It causes swelling between your vertebrae, which are the disks that make up your spine, and in the joints between your spine and pelvis. Ankylosing spondylitis is an autoimmune disease. This means your immune system, which normally protects your body from infection, attacks your body's own tissues. The disease is more common and more severe in men. It often runs in families. Early symptoms include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, ankylosing spondylitis can fuse your vertebrae together, limiting movement. Symptoms can worsen or improve or stop altogether. The disease has no cure, but medicines can relieve the pain, swelling and other symptoms. Exercise can also help.

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Ankylosing spondylitis

Ankylosing spondylitis is a chronic inflammatory disease that primarily causes pain and inflammation of the joints between the vertebrae of your spine and the joints between your spine and pelvis (sacroiliac joints). However, ankylosing spondylitis may also cause inflammation and pain in other parts of your body as well.

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Ankylosing spondylitis

Ankylosing spondylitis (AS) is a type of chronic (long-term) arthritis that affects the bones, muscles and ligaments of the spine.

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Ankylosing Spondylitis, Radiologic Perspective

Ankylosing spondylitis is a type of arthritis that is due to inflammation of multiple joints, characteristically the spinal facet joints and the sacroiliac joints at the base of the spine. While it tends to affect these joints and the soft tissues around the spine, other joints may also be affected as well as tissues around the joints (entheses, where tendons and ligaments attach to bone). This disorder frequently results in bony ankylosis (or fusion). The term ankylosing is derived from the Greek word ankylos, which means stiffening of a joint. Spondylos means vertebra (or spine). Spondylitis refers to inflammation of one or more vertebrae. Ankylosing spondylitis is usually a chronic and progressive form of arthritis. Ankylosing spondylitis may also involve areas of the body other than the joints, such the eyes, heart, and lungs.

Cortisone

Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice, synthetic analogs may be used in conjunction with mineralocorticoids where applicable, in infancy mineralocorticoid supplementation is of particular importance).Congenital adrenal hyperplasiaNonsuppurative thyroiditisHypercalcemia associated with cancer Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:Psoriatic arthritisRheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)Ankylosing spondylitisAcute and subacute bursitisAcute nonspecific tenosynovitisAcute gouty arthritisPost-traumatic osteoarthritisSynovitis of osteoarthritisEpicondylitis Collagen Diseases During an exacerbation or as maintenance therapy in selected cases of:Systemic lupus erythematosusAcute rheumatic carditisSystemic dermatomyositis (polymyositis) Dermatologic Diseases PemphigusBullous dermatitis herpetiformisSevere erythema multiforme (Stevens-Johnson syndrome)Exfoliative dermatitisMycosis fungoidesSevere psoriasisSevere seborrheic dermatitis Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:Seasonal or perennial allergic rhinitisBronchial asthmaContact dermatitisAtopic dermatitisSerum sicknessDrug hypersensitivity reactions Ophthalmic Diseases Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa, such as:Allergic conjunctivitisKeratitisAllergic corneal marginal ulcersHerpes zoster ophthalmicusIritis and iridocyclitisChorioretinitisAnterior segment inflammationDiffuse posterior uveitis and choroiditisOptic neuritisSympathetic ophthalmia Respiratory Diseases Symptomatic...

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Ankylosing spondylitis - Wikipedia, the free encyclopedia

Ankylosing spondylitis (AS, from Greek ankylos, stiff; spondylos, vertebrae), previously known as Bekhterev's disease, Bekhterev syndrome, ...

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Spondylitis Association of America - Ankylosing Spondylitis and ...

Supports education, research and treatment for ankylosing spondylitis and related diseases. Description of the disease, personal stories, online forum, ...

Read more on www.spondylitis.org

Ankylosing Spondylitis Causes, Diagnosis, Information, Symptoms ...

Mar 12, 2011 ... Read about ankylosing spondylitis (a form of chronic inflammation of the spine and the sacroiliac joints), which causes spinal pain and ...

Read more on www.medicinenet.com

Ankylosing Spondylitis: Pain, Symptoms, Treatments, Causes, and More

Information on ankylosing spondylitis, a type of arthritis affecting the spine.

Read more on www.webmd.com

Ankylosing Spondylitis: eMedicine Radiology

Mar 25, 2009 ... Overview: Ankylosing spondylitis is a distinct disease entity characterized by inflammation of multiple articular and para-articular ...

Read more on emedicine.medscape.com

Contents

Complications
Ankylosing spondylitis doesn't follow a set course. The severity of symptoms and development of complications vary widely from person to person. Complications may include: Difficulty walking or standing. Typically, ankylosing spondylitis begins with soreness in your lower back. As the disease progresses, the affected bones may fuse together, rendering your joints immobile and causing a stiff, inflexible spine (bamboo spine). This can make walking or standing difficult. Your joints may fuse even if you undergo proper treatment and once joints fuse, additional treatment won't help restore mobility. However, if fusion occurs with your spine in an upright position, you can remain more able to...

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Coping and support
The course of your condition may change over time, and you may experience relapses and remissions throughout your life. But despite the potential complications, most people are able to live productive lives despite a diagnosis of ankylosing spondylitis.

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Diagnosis
See your GP if you think that you may have ankylosing spondylitis (AS).

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Exams and Tests
Tests may include: CBC ; ESR ; HLA-B27 antigen ; X-rays of the spine and pelvis

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Lifestyle and home remedies
If you smoke, quit. Smoking is bad for your health, but creates additional problems for people with ankylosing spondylitis. Depending on the severity of your condition, ankylosing spondylitis can affect the mobility of your rib cage. Damaging your lungs by smoking can further compromise your ability to breathe.

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Medical advice
Call your health care provider if:You have symptoms of ankylosing spondylitis; You have ankylosing spondylitis and develop new symptoms during treatment

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Outlook (Prognosis)
The course of the disease is unpredictable. Symptoms may come and go at any time. Most people are able to function unless the hips are severely involved.

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Possible Complications
Rarely, people may have problems with the aortic heart valve (aortic insufficiency) and heart rhythm problems.

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Preparing for your appointment
You're likely to start by first seeing your family doctor or a general practitioner. However, he or she will likely refer you to a doctor that specializes in inflammatory disorders (rheumatologist).

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Prevention
Because genetic factors appear to play a part in ankylosing spondylitis, it's not possible to prevent the disease. However, being aware of any personal risk factors for the disease can help in early detection and treatment. Proper and early treatment can relieve joint pain and may help to prevent or delay the onset of physical deformities.

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Risk factors
DS00483

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Self help
If you have been diagnosed with ankylosing spondylitis (AS), the self care advice outlined below may be useful.

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Symptoms
Initial symptoms Early signs and symptoms of ankylosing spondylitis may include: Chronic pain in your lower back and hips, especially in the morning and after periods of inactivity; Stiffness in your lower back or hip area

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Treatments and drugs
The goal of treatment is to relieve your pain and stiffness, and prevent or delay complications and spinal deformity. Ankylosing spondylitis treatment is most successful before the disease causes irreversible damage to your joints, such as fusion, especially in positions that limit your function.

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