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Elspar
Elspar (asparaginase) contains the enzyme L-asparagine amidohydrolase, type EC-2, derived from Escherichia coli. Elspar activity is expressed in terms of International Units according to the recommendation of the International Union of Biochemistry. One International Unit of asparaginase is defined as that amount of enzyme required to generate 1 &micro,mol of ammonia per minute at pH 7.3 and 37°C. The specific activity of Elspar is at least 225 International Units per milligram of protein. Elspar is indicated as a component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia (ALL) (1.1) 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dose 2.2 Instructions for Administration 2.3 Preparation and Handling Precautions 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 5 WARNINGS AND PRECAUTIONS 5.1 Anaphylaxis and Serious Allergic Reactions 5.2 Thrombosis 5.3 Pancreatitis 5.4 Glucose Intolerence 5.5 Coagulopathy 6 ADVERSE REACTIONS 6.1 Clinical Trials and Post-Marketing Experience 6.2 Immunogenicity 7 DRUG INTERACTIONS 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.3 Nursing Mothers 8.4 Pediatric Use 8.5 Geriatric Use 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action 12.2 Pharmacodynamics 12.3 Pharmacokinetics 13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, and Impairment of Fertility 13.2 Animal Toxicology 14 CLINICAL STUDIES 15 REFERENCES 16 HOW SUPPLIED/STORAGE AND HANDLING 17 PATIENT COUNSELING INFORMATION 17.1 Serious Allergic Reactions 17.2 Thrombosis 17.3 Pancreatitis 17.4 Glucose Intolerance FULL PRESCRIBING INFORMATION...
Chemotherapy - Wikipedia, the free encyclopedia
In its non-oncological use, the term may also refer to antibiotics (antibacterial chemotherapy). In that sense, the first modern chemotherapeutic agent was ...
chemotherapeutic agent - definition of chemotherapeutic agent in ...
chemotherapeutic agent. [-ther′əpyo̅o̅′tik]. any chemical used to treat cancer. It is usually used to refer to antineoplastic drugs. ...
Categories of Chemotherapeutic Agents
Jul 2, 2010 ... Categories include alkylating agents (including platinum compounds), anthracyclines, antimetabolites, antibiotics, monoclonal antibodies, ...
chemotherapeutic agent
Home → Dictionary → C → chemotherapeutic agent. chemotherapeutic agent. Email to a friend; Print. Page last modified on: June 5, 2008 ...
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All personnel working with chemotherapeutic agents must read the agentÕs Material Safety Data Sheet (MSDS) to address the requirement for hazard awareness ...
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Chemotherapy for Pancreatic Cancer: Chemotherapy Agents in ...
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of these chemotherapeutic agents. It will be the task ...
by F Craig