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What is Cymbalta?
Cymbalta (duloxetine hydrochloride) is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Its chemical designation is (+)-(S)- N -methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride. The empirical formula is C18H19NOS•HCl, which corresponds to a molecular weight of 333.88. The structural formula is: Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water.
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Also known as duloxetine, duloxetine hydrochloride, LY-248686, LY 248686, LY227942, N-methyl-3-(1-naphthalenyloxy)-2-thiophenepropanamine, LY 227942
Cymbalta information from trusted sources:
Cymbalta (Duloxetine Hcl) Drug Information: User Reviews, Side ...
Learn about the prescription medication Cymbalta (Duloxetine Hcl), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient ... Read more on
www.rxlist.com
Definition of Cymbalta - NCI Dictionary of Cancer Terms
Cymbalta increases the amount of certain chemicals in the brain that help relieve depression and pain. It is a type of serotonin and norepinephrine reuptake ... Read more on
www.cancer.gov
Cymbalta User Reviews for Depression at Drugs.com
I was switched to Cymbalta yesteray by my doctor and when I read so many negative reviews I started getting really nervous. I am hoping that this drug is a ... Read more on
www.drugs.com
Cymbalta
Cymbalta (duloxetine hydrochloride) is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Its chemical designation is (+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride. The empirical formula is C18H19NOS&bull,HCl, which corresponds to a molecular weight of 333.88. The structural formula is:Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water. Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for: 1.1 Major Depressive Disorder 1.2 Generalized Anxiety Disorder 1.3 Diabetic Peripheral Neuropathic Pain 1.4 Fibromyalgia 2 DOSAGE AND ADMINISTRATION 2.1 Initial Treatment 2.2 Maintenance/Continuation/Extended Treatment 2.3 Dosing in Special Populations 2.4 Discontinuing Cymbalta 2.5 Switching Patients to or from a Monoamine Oxidase Inhibitor 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 4.1 Monoamine Oxidase Inhibitors 4.2 Uncontrolled Narrow-Angle Glaucoma 5 WARNINGS AND PRECAUTIONS 5.1 Clinical Worsening and Suicide Risk 5.2 Hepatotoxicity 5.3 Orthostatic Hypotension and Syncope 5.4 Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like Reactions 5.5 Abnormal Bleeding 5.6 Discontinuation of Treatment with Cymbalta 5.7 Activation of Mania/Hypomania 5.8 Seizures 5.9 Effect on Blood Pressure 5.10 Clinically Important Drug Interactions 5.11 Hyponatremia 5.12 Use in Patients with Concomitant Illness 5.13 Urinary Hesitation and Retention 5.14 Laboratory Tests 6 ADVERSE REACTIONS 6.1 Clinical Trial Data Sources 6.2 Adverse Reactions Reported as Reasons for Discontinuation of Treatment in Placebo-Controlled Trials 6.3 Adverse Reactions Occurring at an Incidence of 5% or More and at least Twice Placebo Among Duloxetine-Treated Patients in Placebo-Controlled Trials 6.4 Adverse Reactions Occurring at an Incidence of 5% or More Among Duloxetine-Treated Patients in Placebo-Controlled Trials 6.5 Adverse Reactions Occurring at an... Read more on
dailymed.nlm.nih.gov
Cymbalta (duloxetine) Drug Side Effects, Interactions, and ...
Drug information on Cymbalta (duloxetine), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to ... Read more on
www.emedicinehealth.com
Contents
Brand Names and Description
Duloxetine is used to treat mental depression and generalized anxiety disorder. It is also used for pain caused by nerve damage associated with diabetes.
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www.mayoclinic.com
Drug Interactions, Overdosage and Contraindications
In postmarketing experience, fatal outcomes have been reported for acute overdoses, primarily with mixed overdoses, but also with duloxetine only, at doses as low as 1000 mg. Signs and symptoms of overdose (duloxetine alone or with mixed drugs) included somnolence, coma, serotonin syndrome, seizures, syncope, tachycardia, hypotension, hypertension, and vomiting.
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FDA Alerts
A life-threatening condition called serotonin syndrome can happen when medicines called selective serotonin/norepinephrine reuptake inhibitors (SNRIs), such as Cymbalta, and medicines used to treat migraine headaches known as 5-hydroxytryptamine receptor agonists (triptans), are used together... More about this FDA Alert
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Indications and Dosage
Cymbalta is indicated for the acute and maintenance treatment of major depressive disorder (MDD) [see Clinical Studies (14.1)].
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www.druglib.com
Other Rx Information
In animal studies, duloxetine did not demonstrate barbiturate-like (depressant) abuse potential.
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www.druglib.com
Precautions
It is important that your doctor check your progress at regular visits, to allow for changes in your dose and to help reduce any side effects.
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www.mayoclinic.com
Proper Use
Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
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www.mayoclinic.com
Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
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www.mayoclinic.com
Summary
Cymbalta (duloxetine hydrochloride) is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration.
Read more on
www.druglib.com