What is lewy body disease?

Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss of mental functions severe enough to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, build up in areas of the brain. The disease may cause a wide range of symptoms, including Lewy body disease can be hard to diagnose, because Parkinson's disease and Alzheimer's disease cause similar symptoms. Scientists think that Lewy body disease might be related to these diseases, or that they sometimes happen together.

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Dementia With Lewy Bodies

Dementia is a progressive (gradually worsening) decline of mental abilities that disturbs "cognitive" functions such as memory, thought processes, and speech as well as behavior, and movements. Dementia with Lewy bodies (DLB) is the name for a group of disorders in which dementia is caused by the presence of Lewy bodies in the brain. Lewy bodies are small round clumps of normal proteins that for unknown reasons become abnormally clumped together inside neurons (brain cells). Whether the Lewy bodies directly cause gradual degeneration (damage) to the brain cells, impairing their function and eventually killing them, or are only a marker of some other destructive process is not known. Lewy bodies are named after Frederich Lewy, the doctor who first described them in 1912. Dr. Lewy first found Lewy bodies in the brains of people with Parkinson disease. Parkinson disease is a condition best known for disrupting body movements. The most common of these "motor" symptoms are tremor (shaking or trembling) of the hands (that mainly occurs when the hands are at rest and not moving), rigidity (stiffness) of the trunk and limbs, slowness of movement, and loss of balance and coordination. Estimates vary from 30-60% about what percentage of people with Parkinson disease develop dementia. Scientists later discovered cases of Alzheimer-type dementia linked to Lewy bodies. This was thought to be very rare, but as tests of brain tissue improved, it became clear that Lewy bodies were fairly common and were linked to several different types of dementia. A type of dementia similar to but different from Alzheimer disease was recognized and called DLB. DLB is now believed to be the second or third most common type of dementia after Alzheimer disease, accounting for about 10-20% of all dementias. (There is controversy about whether DLB or vascular dementia is the second most common form of dementia.) The relationship between DLB and Parkinson disease is not completely understood. When motor symptoms appear first and predominate over cognitive symptoms, the diagnosis is believed to be Parkinson disease. When cognitive impairment and behavioral disturbances are prominent early symptoms, DLB is believed to be the diagnosis. DLB is a disease of aging. People affected by DLB are usually elderly or in late middle age.

Chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease, or COPD, is a long-term lung disease that causes breathing problems. The term COPD is used to describe certain diseases that partially block airflow in the lungs. The most common kinds of COPD include:Emphysema: Emphysema (em-fi-SEE-mah) causes damage to the alveoli (al-VEE-oh-lie) that cannot be reversed (cured). The alveoli are the tiny air sacs of the lungs where oxygen is put into your blood. With emphysema, your lungs become less able to take in oxygen (good air) and get rid of carbon dioxide (deye-OKS-eyed). Carbon dioxide is an invisible gas that your body gives off as a waste product.

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Welcome to the Lewy Body Dementia Association

The Lewy Body Dementia Association (LBDA) is a 501(c)(3) nonprofit organization dedicated to raising awareness of the Lewy body dementias (LBD)

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Dementia with Lewy bodies - Wikipedia, the free encyclopedia

Dementia with Lewy bodies (DLB), also known under a variety of other names including Lewy body dementia, diffuse Lewy body disease, cortical Lewy body ...

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Lewy Body Dementia - Diagnosis and Treatment Options at Mayo Clinic

Mayo Clinic researchers study risk factors, diagnostic techniques and treatment options for Lewy body dementia, Alzheimer's disease and other conditions. ...

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Dementia With Lewy Bodies Information Page: National Institute of ...

Nov 19, 2010 ... Microsoft Word Viewer. Synonym(s): Lewy Body Dementia ... The similarity of symptoms between DLB and Parkinson's disease, and between DLB ...

Read more on www.ninds.nih.gov

Dementia With Lewy Bodies: eMedicine Neurology

Sep 27, 2010 ... Lewy body dementia, DLB, LB, Lewy body variant of Alzheimer disease, diffuse Lewy body disease, senile dementia of the Lewy body type, ...

Read more on emedicine.medscape.com

Parkinson's disease

Parkinson's disease is a chronic (persistent) neurological condition that affects around 120,000 people in the UK. The condition is named after Dr James Parkinson, who first identified it in 1817. Parkinson's disease affects the way the brain coordinates body movements, including walking, talking, and writing.

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FCA: Dementia with Lewy Bodies

Cerebral type of Lewy body disease. Neuropathology, 16:32-5. ... Neuropsychological deficits associated with diffuse Lewy body disease. ...

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LBD - Lewy Body Dementia Association

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Lewy body dementia
Lewy body dementia shares characteristics with both Alzheimer's disease and Parkinson's disease. Like Alzheimer's, it causes confusion. Like Parkinson's, it can result in rigid muscles, slowed movement and tremors.

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Parkinson's disease
No definitive tests exist for Parkinson's disease, so it can be difficult to diagnose, especially in the early stages. And parkinsonism the symptoms of Parkinson's disease can be caused by many other types of problems. Examples include: Other neurological disorders. Essential tremor, dementia with Lewy bodies, multiple system atrophy and progressive supranuclear palsy each feature some symptoms common to Parkinson's disease. Drugs. Antipsychotic medications such as chlorpromazine (Thorazine) and haloperidol (Haldol) block dopamine, as do anti-nausea drugs like prochlorperazine (Compazine) or metoclopramide (Reglan). If you take any of these drugs, you may develop parkinsonism, although it...

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Vascular dementia
Vascular dementia is an umbrella term that describes impairments in cognitive function caused by problems in blood vessels that feed the brain.

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Chronic brain syndrome, Lewy body dementia, DLB, Vascular dementia, Mild cognitive impairment, MCI

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Rivastigmine is also used sometimes to treat Lewy body dementia (a condition in which the brain develops abnormal protein structures, and the brain and nervous system are destroyed over time). Talk to your doctor about the possible risks of using this medication for your condition.

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Behcet's disease
Behcet's (beh-CHETS) disease, also called Behcet's syndrome, is a rare disorder that causes chronic inflammation in blood vessels throughout your body. The inflammation of Behcet's disease leads to a variety of symptoms that may initially seem unrelated.

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Mad Cow Disease and Variant Creutzfeldt-Jakob Dis
Mad cow is an infectious disease in the brain of cattle. Humans who become infected, usually by eating tissue from diseased cattle, will die of a similar brain disease that may develop over many years. Abnormal proteins called prions (PRE-ons) are found in brain tissue of diseased cattle. Prions eat away at the brain and create tiny spongelike holes in parts of the brain. These so-called spongy holes cause slow deterioration within the cattle brain, and eventually symptoms affecting the whole body. Death follows. The scientific name for mad cow disease in cattle is called bovine spongiform encephalopathy (meaning sick brain) or BSE, meaning a sickness of the cows brain, when damaged brain tissue is viewed on a laboratory slide, it has a spongy appearance.

Autoimmune Diseases
Your body's immune system protects you from disease and infection. But if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Autoimmune diseases can affect many parts of the body. These diseases tend to run in families. Women - particularly African-American, Hispanic-American, and Native-American women - have a higher risk for some autoimmune diseases. There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting diagnosed can be frustrating and stressful. In many people, the first symptoms are being tired, muscle aches and low fever.

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Iron overload disease
Hemochromatosis is an inherited disease in which too much iron builds up in your body. It is one of the most common genetic diseases in the United States. Iron is a mineral found in many foods. Your body normally absorbs about 10 percent of the iron in the food you eat. If you have hemochromatosis, you absorb more iron than you need. Your body has no natural way to get rid of the extra iron. It stores it in body tissues, especially the liver, heart and pancreas. The extra iron can damage your organs. Without treatment, it can cause your organs to fail.

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Raynaud's disease
Raynaud's disease is a disorder in which the blood vessels to the fingers and toes (digits) become abnormally closed off (constricted). The fingers and toes of individuals with Raynaud's disease change color from white to blue to red, often causing them to feel numb. Raynaud's disease is sometimes seen with autoimmune diseases, such as rheumatoid arthritis, scleroderma, and lupus, where the body's immune system turns against itself, causing various symptoms. Other causes of Raynaud's disease include repeated trauma/vibration, abnormalities in the structure of blood vessels, and drug injection into one type of blood vessel (arteries).

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Wilson's disease
Wilson's disease causes a wide variety of signs and symptoms that are often mistaken for other diseases and conditions. Signs and symptoms vary depending on what parts of your body are affected by Wilson's disease.

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