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What is Morphine?
Chemically, morphine sulfate is 7, 8-didehydro-4, 5α-epoxy-17-methylmorphinan-3, 6α-diol sulfate (2:1) (salt) pentahydrate. The molecular formula is (C17H19NO3)2·H2SO4·5H2O; and the molecular weight is 758.83. The structural formula is as follows: Each morphine sulfate extended-release tablet, for oral administration, contains 15 mg, 30 mg, 60 mg, 100 mg, or 200 mg of morphine sulfate. In addition, each tablet contains the following inactive ingredients: colloidal silicon...
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Also known as Morphine Sulfate, MS Contin, Morphia, Oramorph SR, Duramorph, Morphine Chloride, astramorph, roxanol
Morphine information from trusted sources:
Morphine
Each extended-release tablet, for oral administration contains 100 mg of morphine sulfate USP. Morphine sulfate is an opioid analgesic. Read more on
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MS Contin
Chemically, morphine sulfate is 7,8-didehydro-4,5α-epoxy-17-methylmorphinan-3,6α-diol sulfate (2:1) (salt) pentahydrate and has the following structural formula:MS CONTIN (morphine sulfate controlled-release) Tablets are opiate analgesics supplied in 15, 30, 60, 100 and 200 mg tablet strengths. The tablet strengths describe the amount of morphine per tablet as the pentahydrated sulfate salt (morphine sulfate, USP). MS CONTIN Controlled-release Tablets 15 mg, 30 mg, 60 mg, 100 mg, and 200 mg contain the following inactive ingredients: cetostearyl alcohol, hydroxyethyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, talc and titanium dioxide. MS CONTIN Tablets are a controlled-release oral formulation of morphine sulfate indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time. Read more on
dailymed.nlm.nih.gov
MS Contin
MS Contin, a controlled-release tablet containing morphine, is used to relieve moderate to severe pain. While regular morphine is usually given every 4 hours, MS Contin is typically taken every 12 hoursonly twice a day. The Kadian brand may be taken once or twice a day. The drugs are intended for people who need a morphine painkiller for more than just a few days. Read more on
www.pdrhealth.com
Morphine Oral
Morphine is used to relieve moderate to severe pain. Morphine long-acting tablets and capsules are only used by patients who are expected to need medication to relieve moderate to severe pain around-the-clock for longer than a few days. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the body senses pain. Read more on
www.nlm.nih.gov
Morphine overdose
Morphine is a very strong painkiller. Morphine overdose occurs when a person intentionally or accidentally takes too much of the medicine. This is for information only and not for use in the treatment or management of an actual poison exposure. If you have an exposure, you should call your local emergency number (such as 911) or the National Poison Control Center at 1-800-222-1222. Read more on
www.nlm.nih.gov
Contents
Drug Interactions, Overdosage and Contraindications
The concomitant use of other central nervous system depressants including sedatives or hypnotics, general anesthetics, phenothiazines, tranquilizers and alcohol may produce additive depressant effects. Respiratory depression, hypotension and profound sedation or coma may occur. When such combined therapy is contemplated, the dose of one or both agents should be reduced. Opioid analgesics, including morphine sulfate extended-release tablets, may enhance the neuromuscular blocking action of skeletal...
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Indications and Dosage
Morphine sulfate extended-release tablets are indicated for the relief of moderate to severe pain. It is intended for use in patients who require repeated dosing with potent opioid analgesics over periods of more than a few days.
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Other Rx Information
Opioid analgesics may cause psychological and physical dependence (see WARNINGS). Physical dependence results in withdrawal symptoms in patients who abruptly discontinue the drug or may be precipitated through the administration of drugs with opioid antagonist activity, e.g., naloxone or mixed agonist/antagonist analgesics (pentazocine, etc.; See also OVERDOSAGE). Physical dependence usually does not occur to a clinically significant degree until after several weeks of continued opioid usage....
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Side Effects and Adverse Reactions
The adverse reactions caused by morphine are essentially those observed with other opioid analgesics. They include the following major hazards: respiratory depression, apnea, and to a lesser degree, circulatory depression, respiratory arrest, shock and cardiac arrest.
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Summary
Each extended-release tablet, for oral administration contains 100 mg of morphine sulfate USP. Morphine sulfate is an opioid analgesic.
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Warnings and Precautions
Respiratory depression is the chief hazard of all morphine preparations. Respiratory depression occurs most frequently in the elderly and debilitated patients, as well as in those suffering from conditions accompanied by hypoxia or hypercapnia when even moderate therapeutic doses may dangerously decrease pulmonary ventilation.
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