pagetdisease

What is paget disease?


Paget disease of the bone is the second most common bone disorder in elderly patients. (Osteoporosis is the most common.) Paget disease is a disorder that affects the normal remodeling process of bone. In normal bone, the bone constantly remodels. In the remodeling process, old bone is removed and new bone is formed. In patients with Paget disease, this process is altered. These patients have an excessive amount of bone resorption (removal) followed by an even more excessive amount of new bone formation. Unfortunately, this increased rate of bone remodeling leads to new bone that is not as strong as normal bone. This abnormal bone is weaker, has more blood vessels, and is larger in size than normal bone. While most cases do not cause symptoms, some patients may develop pain, fractures, or even malignant transformation into sarcoma (bone tumor), although this is rare.

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Gum disease

Any abnormality, inflammatory or degenerative, of the tissue around a tooth. (Periodontal means "located around a tooth") The term refers to any disorder of the gums or other supporting structures of the teeth. Periodontitis is the inflammation or degeneration, or both, of the dental periosteum, alveolar bone, cementum, and adjacent gingiva. Suppuration ususally occurs, supporting bone is resorbed, teeth become loose, and recession of gingivae occurs. Usually follows chronic gingivitis, Vincent's infection, or poor dental hygiene.

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Paget's Disease Symptoms, Diagnosis, Treatment, Causes and ...

Mar 16, 2011 ... Read about Paget's disease causes, symptoms, statistics, prognosis, diagnosis and treatment. Learn about Sir James Paget, who discovered the ...

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Paget's disease - Wikipedia, the free encyclopedia

Sir James Paget, a surgeon and pathologist, described several diseases, including: Paget's disease of bone (most common use of Paget's disease) ...

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Paget Disease of the Nipple - National Cancer Institute

A fact sheet about Paget disease of the nipple, an uncommon type of breast cancer that is sometimes called mammary Paget's disease.

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Physical Medicine and Rehabilitation for Paget Disease: eMedicine ...

Dec 18, 2008 ... Overview: Paget's disease (Paget disease), characterized by excessive and abnormal remodeling of bone, is a common disorder in middle-aged ...

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Paget disease definition - Medical Dictionary definitions of ...

Mar 14, 2011 ... Paget disease: A chronic bone disorder that typically results in enlarged, deformed bones due to excessive breakdown and formation of bone ...

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Paget's Disease of Bone - Your Orthopaedic Connection - AAOS

Paget's disease of bone is a chronic disease of the skeleton. It is a common disease in older people, occurring in about 3 percent to 4 percent of the ...

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Tiludronate

The safety of SKELID has been studied in more than 1100 patients, and the adverse experience profile is similar between controlled and uncontrolled clinical trials. Adverse events occurring in placebo-controlled trials of pagetic patients treated with SKELID 400 mg/day are presented in the table below.

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Raynaud's disease

Raynaud's disease is a disorder in which the blood vessels to the fingers and toes (digits) become abnormally closed off (constricted). The fingers and toes of individuals with Raynaud's disease change color from white to blue to red, often causing them to feel numb. Raynaud's disease is sometimes seen with autoimmune diseases, such as rheumatoid arthritis, scleroderma, and lupus, where the body's immune system turns against itself, causing various symptoms. Other causes of Raynaud's disease include repeated trauma/vibration, abnormalities in the structure of blood vessels, and drug injection into one type of blood vessel (arteries).

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Chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease, or COPD, is a long-term lung disease that causes breathing problems. The term COPD is used to describe certain diseases that partially block airflow in the lungs. The most common kinds of COPD include:Emphysema: Emphysema (em-fi-SEE-mah) causes damage to the alveoli (al-VEE-oh-lie) that cannot be reversed (cured). The alveoli are the tiny air sacs of the lungs where oxygen is put into your blood. With emphysema, your lungs become less able to take in oxygen (good air) and get rid of carbon dioxide (deye-OKS-eyed). Carbon dioxide is an invisible gas that your body gives off as a waste product.

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Contents

Osteitis deformans
Paget's disease of bone causes your bones to grow larger and weaker than normal. They also might break easily. The disease can lead to other health problems, too, such as arthritis and hearing loss. You can have Paget's disease in any bone, but it is most common in the spine, pelvis, skull and legs. The disease might affect one or several bones, but not your entire skeleton. More men than women have the disease. It is most common in older people. Many people do not know they have Paget's disease because their symptoms are mild. For others, symptoms can include

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Paget's disease of bone
Paget's disease of bone is a condition affecting how your bone breaks down and rebuilds. Healthy bone metabolism allows for old bone to be recycled into new bone throughout your life.

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Paget's disease of the breast
Subscribe to our Living with cancer newsletter to stay up to date on cancer topics.

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Paget's disease
To get a better understanding of how Paget's disease affects your bones, it is useful to understand how your bones grow.

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Paget's Disease of Breast
Breast cancer affects one in eight women during their lives. Breast cancer kills more women in the United States than any cancer except lung cancer. No one knows why some women get breast cancer, but there are a number of risk factors. Risks that you cannot change include Other risks include being overweight, using hormone replacement therapy, taking birth control pills, drinking alcohol, not having children or having your first child after age 35 or having dense breasts.

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Temporal arteritis
Paget SA, Spiera RF. Polymyalgia Rheumatica and Temporal Arteritis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier, 2007:chap 292.

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Eye Diseases
Some eye problems are minor and fleeting. But some lead to a permanent loss of vision. Common eye problems include Your best defense is to have regular checkups, because eye diseases do not always have symptoms. Early detection and treatment could prevent vision loss. See an eye care professional right away if you have a sudden change in vision or everything looks dim or if you see flashes of light. Other symptoms that need quick attention are pain, double vision, fluid coming from the eye and inflammation.

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Diabetic Eye Disease
Diabetes mellitus is one of the leading causes of irreversible blindness worldwide, and, in the United States, it is the most common cause of blindness in people younger than 65 years of age. In addition to being a leading cause of blindness, diabetic eye disease encompasses a wide range of problems that can affect the eyes.

Periodontal Disease
If you have gum disease, you're not alone. About 80 percent of U.S. adults currently have some form of the disease. It ranges from simple gum inflammation, called gingivitis, to serious disease that results in damage to the bone. In gingivitis, the gums become red and swollen. They can bleed easily. Most people can reverse this with daily brushing and flossing and seeing their dentist regularly. Untreated gingivitis can lead to periodontitis. The gums pull away from the teeth and form pockets that are infected. If not treated, the bones, gums and connective tissue that support the teeth are destroyed.

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Gum disease
Gingivitis (often referred to as gum disease) causes your gums to become red, inflamed and swollen. It can cause your gums to bleed when you brush your teeth.

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Alzheimer's Disease FAQs
Alzheimer's disease is a progressive and fatal brain disorder that gradually destroys a person's memory and ability to learn, reason, communicate, and make judgments.