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What is Parkinson Disease?
Parkinson disease (PD) is an age-related deterioration of certain nerve systems, which affects your movement, balance, and muscle control. Parkinson disease is one of the most common movement disorders, affecting 1% of people older than 60 years. PD is about 1.5 times more common in men than in women, and it becomes more common as you age. The average age of onset is about 60 years. Onset before age 40 years is relatively uncommon, but the recent diagnosis of actor Michael J. Fox shows that younger people are also vulnerable. In PD, brain cells deteriorate (or degenerate) in an area of the brain called the substantia nigra. From the substantia nigra, specific nerve cell tracts connect to another part of the brain called the corpus striatum, where the neurotransmitter (a chemical messenger in the brain) called dopamine is released. Dopamine is an important neurotransmitter and alterations in its concentration can lead to different medical problems. The loss of these specific brain cells and decline in dopamine concentration are the cornerstone of signs and symptoms of PD as well as the target for treatment. The biological mechanism responsible for the brain cell loss has not been identified.
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Also known as Parkinson's Disease, Idiopathic Parkinson Disease, Idiopathic Parkinson's Disease, Paralysis Agitans, Primary Parkinsonism, Lewy Body Parkinson Disease, Lewy Body Parkinson's Disease
Parkinson Disease information from trusted sources:
Parkinson's disease
Parkinson's disease is a disorder that affects nerve cells, or neurons, in a part of the brain that controls muscle movement. In Parkinson's, neurons that make a chemical called dopamine die or do not work properly. Dopamine normally sends signals that help coordinate your movements. No one knows what damages these cells. Symptoms of Parkinson's disease may include As symptoms get worse, people with the disease may have trouble walking, talking or doing simple tasks. They may also have problems such as depression, sleep problems or trouble chewing, swallowing or speaking. Read more on
www.nlm.nih.gov
Parkinson's disease
Parkinson's disease is a chronic (persistent) neurological condition that affects around 120,000 people in the UK. The condition is named after Dr James Parkinson, who first identified it in 1817. Parkinson's disease affects the way the brain coordinates body movements, including walking, talking, and writing. Read more on
www.nhs.uk
Parkinson's disease
Parkinson's disease (PD) is a slowly progressive neurological disorder with primary symptoms of resting tremor, slowness, stiffness, and problems with balance. Parkinson's disease (PD) occurs equally often in men and women, and occurs with similar frequency in all ethnic groups.The disease is usually diagnosed in people between the ages of 45 and 65. Read more on
www.pdrhealth.com
Parkinson's Disease Center: Symptoms, Treatments, Causes, Tests ...
Parkinson's disease is diagnosed in more than 50000 Americans each year. Find Parkinson's disease information here including symptoms and treatments -- from ... Read more on
www.webmd.com
Parkinson's Disease Stages, Symptoms, Causes, and Prognosis by ...
Mar 10, 2011 ... The primary symptoms of Parkinson's disease are all related to voluntary and involuntary motor function and usually start on one side of the ... Read more on
www.medicinenet.com
National Parkinson Foundation - Home
Registration Open for 2011 Midwest Parkinson's Disease Conference and Young Onset Parkinson ... Ask any questions that you have about Parkinson's disease. ... Read more on
www.parkinson.org
The Michael J. Fox Foundation for Parkinson's Research
MJFF is dedicated to finding a cure for Parkinson's disease through an aggressively funded research agenda and to ensuring the development of improved ... Read more on
www.michaeljfox.org
Parkinson's Disease Foundation (PDF) - Hope through Research ...
Mar 22, 2010 ... A national nonprofit dedicated to Parkinson's disease research, education and advocacy. PDF is working for the nearly one million people in ... Read more on
www.pdf.org
Parkinson's Disease Signs & Symptoms - Parkinson's Disease ...
Sep 17, 2010 ... Parkinsons disease symptoms, a detailed list and explanations of symptoms, including tremor, slow movement, and parkinsonian gait. Read more on
www.neurologychannel.com
Parkinson's Disease
A person with Parkinson's disease gradually loses the ability to totally control body movements. Find out more about this disease that most often affects ... Read more on
kidshealth.org
Contents
Parkinson's disease
Parkinson's disease develops gradually, often starting with a barely noticeable tremor in just one hand. But while tremor may be the most well-known sign of Parkinson's disease, the disorder also commonly causes a slowing or freezing of movement.
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www.mayoclinic.com
Parkinson's disease - resources
The following organizations are good resources for information on Parkinson's disease: National Parkinson Foundation - www.parkinson.org Michael J. Fox Foundation for Parkinson's Research - www.michaeljfox.com Parkinson's Disease Foundation, Inc. - www.pdf.org
Read more on
www.nlm.nih.gov
Lewy Body Disease
Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss of mental functions severe enough to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, build up in areas of the brain. The disease may cause a wide range of symptoms, including Lewy body disease can be hard to diagnose, because Parkinson's disease and Alzheimer's disease cause similar symptoms. Scientists think that Lewy body disease might be related to these diseases, or that they sometimes happen together.
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www.nlm.nih.gov
Parkinson Disease Dementia
Parkinson disease (PD) is a degenerative disorder of the brain. It mainly affects movements of the body. The most common symptoms are tremor (shaking or trembling) of the hands, arms, jaw, and face, rigidity (stiffness) of the trunk and limbs, slowness of movement, and loss of balance and coordination. Other symptoms include shuffling, speaking difficulties, (or speaking very softly), facial masking (expressionless, mask-like face), swallowing problems, and stooped posture. The symptoms worsen gradually. Depression, anxiety, personality and behavior changes, sleep disturbances, and sexual problems are commonly associated with PD. In many cases, PD does not affect a persons ability to think, reason, learn, or remember (cognitive processes).
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www.emedicinehealth.com
Secondary parkinsonism
Selegiline
Selegiline Hydrochloride Tablets USP are indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy.
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www.druglib.com
Ropinirole
Requip (ropinirole hydrochloride), an orally administered anti-Parkinsonian drug, is a non-ergoline dopamine agonist.
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www.druglib.com
Eldepryl
ELDEPRYL (selegiline hydrochloride) is a levorotatory acetylenic derivative of phenethylamine. It is commonly referred to in the clinical and pharmacological literature as l-deprenyl. ELDEPRYL is indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy.
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dailymed.nlm.nih.gov
selegiline hydrochloride
Selegiline hydrochloride is a levorotatory acetylenic derivative of phenethylamine. It is commonly referred to in the clinical and pharmacological literature as l-deprenyl. Selegiline hydrochloride is indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy.
Read more on
dailymed.nlm.nih.gov
Parkinson's disease - Wikipedia, the free encyclopedia
Parkinson's disease (also known as Parkinson disease, Parkinson's, idiopathic parkinsonism, primary parkinsonism, PD or paralysis agitans) is a degenerative ...
Read more on
en.wikipedia.org
Parkinson's Disease Information Page: National Institute of ...
Parkinson's disease information compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Read more on
www.ninds.nih.gov