pentosanpolysulfate

What is pentosan polysulfate?


Pentosan polysulfate sodium is a semi-synthetically produced heparin-like macromolecular carbohydrate derivative, which chemically and structurally resembles glycosaminoglycans. It is a white odorless powder, slightly hygroscopic and soluble in water to 50% at pH 6. It has a molecular weight of 4000 to 6000Dalton with the following structural formula: ELMIRON® is supplied in white opaque hard gelatin capsules containing 100 mg pentosan polysulfate sodium, microcrystalline cellulose, and...

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Elmiron

Pentosan polysulfate sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects. Pentosan polysulfate sodium is a semi-synthetically produced heparin-like macromolecular carbohydrate derivative, which chemically and structurally resembles glycosaminoglycans. It is a white odorless powder, slightly hygroscopic and soluble in water to 50% at pH 6.

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Pentosan Polysulfate

Pentosan polysulfate is used to relieve bladder pain and discomfort related to interstitial cystitis, a disease that causes swelling and scarring of the bladder wall. Pentosan polysulfate is similar to a class of medications called low molecular weight heparins. It works by preventing irritation of the bladder walls.

Read more on www.nlm.nih.gov

Elmiron

Pentosan polysulfate sodium is a semi-synthetically produced heparin-like macromolecular carbohydrate derivative, which chemically and structurally resembles glycosaminoglycans. It is a white odorless powder, slightly hygroscopic and soluble in water to 50% at pH 6. It has a molecular weight of 4000 to 6000 Dalton with the following structural formula:ELMIRON is supplied in white opaque hard gelatin capsules containing 100 mg pentosan polysulfate sodium, microcrystalline cellulose, and magnesium stearate. It also contains pharmaceutical glaze (modified) in SD-45, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake, n-butyl alcohol, propylene glycol, SDA-3A alcohol, and titanium dioxide. It is formulated for oral use. ELMIRON (pentosan polysulfate sodium) is indicated for the relief of bladder pain or discomfort associated with interstitial cystitis.

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Elmiron

Pentosan is used to relieve the symptoms of the bladder condition called interstitial cystitis.

Read more on www.mayoclinic.com

Pentosan polysulfate - Wikipedia, the free encyclopedia

Pentosan polysulfate (sold under the name Elmiron by Ortho-McNeil Pharmaceutical, inc.) is the only oral medication approved by the U.S. FDA for the ...

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Elmiron (Pentosan Polysulfate Sodium Capsules) Drug Information ...

Feb 4, 2009 ... Learn about the prescription medication Elmiron (Pentosan Polysulfate Sodium Capsules), drug uses, dosage, side effects, drug interactions, ...

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pentosan polysulfate sodium medical facts from Drugs.com

Dec 15, 2010 ... Physician reviewed pentosan polysulfate sodium patient information - includes pentosan polysulfate sodium description, ...

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BioMed Central | Full text | Sodium pentosan polysulfate resulted ...

by K Kumagai - 2010 - Cited by 1 - Related articles

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PENTOSAN POLYSULFATE SODIUM - ORAL (Elmiron) side effects, medical ...

Mar 14, 2011 ... Consumer information about the medication PENTOSAN POLYSULFATE ... Read more about the prescription drug PENTOSAN POLYSULFATE SODIUM - ORAL.

Read more on www.medicinenet.com

Effectiveness and Safety Study of Pentosan Polysulfate Sodium for ...

Jul 7, 2004 ... The purpose of this study is to evaluate the safety and effectiveness of pentosan polysulfate sodium 100 mg once a day, pentosan polysulfate ...

Read more on clinicaltrials.gov

Contents

Brand names
Elmiron

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Drug Interactions, Overdosage and Contraindications
ELMIRON drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources. , OVERDOSAGE

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In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

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Indications and Dosage
ELMIRON® (pentosan polysulfate sodium) is indicated for the relief of bladder pain or discomfort associated with interstitial cystitis.

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Medicine storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

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Missed dose
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

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Other information
Keep all appointments with your doctor. Your doctor will examine you after 3 months to see if your symptoms have improved.

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Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

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Proper use
Pentosan polysulfate comes as a capsule to take by mouth. It is usually taken with water three times a day, 1 hour before or 2 hours after meals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pentosan polysulfate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

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Side Effects and Adverse Reactions
ELMIRON® was evaluated in clinical trials in a total of 2627 patients (2343 women, 262men, 22 unknown) with a mean age of 47 [range 18 to 88 with 581 (22%) over 60 years of age]. Of the 2627 patients, 128 patients were in a 3 month trial and the remaining 2499 patients were in a long term, unblinded trial.

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Special diatery instructions
Unless your doctor tells you otherwise, continue your normal diet.

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Special precautions
Before taking pentosan polysulfate,tell your doctor and pharmacist if you are allergic to pentosan polysulfate, danaparoid (Orgaran), heparin, or any other medications..

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Summary
Pentosan polysulfate sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects. Pentosan polysulfate sodium is a semi-synthetically produced heparin-like macromolecular carbohydrate derivative, which chemically and structurally resembles glycosaminoglycans. It is a white odorless powder, slightly hygroscopic and soluble in water to 50% at pH 6.

Read more on www.druglib.com
Uses
Pentosan polysulfate is used to relieve bladder pain and discomfort related to interstitial cystitis, a disease that causes swelling and scarring of the bladder wall. Pentosan polysulfate is similar to a class of medications called low molecular weight heparins. It works by preventing irritation of the bladder walls.

Read more on www.nlm.nih.gov
Warnings and Precautions
ELMIRON® is a weak anticoagulant (1/15 the activity of heparin). At a daily dose of 300 mg (n = 128), rectal hemorrhage was reported as an adverse event in 6.3% of patients. Bleeding complications of ecchymosis, epistaxis, and gum hemorrhage have been reported (see ADVERSE REACTIONS). Patients undergoing invasive procedures or having signs/symptoms of underlying coagulopathy or other increased risk of bleeding (due to other therapies such as coumarin anticoagulants, heparin, t-PA, streptokinase,...

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