What is peripheral vascular disease?

The circulatory system consists of 2 types of blood vessels: arteries and veins. These are tubular structures that carry the blood throughout the body. Arteries carry oxygen- and nutrient-rich blood from the heart to the organs and cells. Veins carry oxygen-depleted blood and wastes through the kidneys, liver, and lungs, where wastes are filtered out and removed from the body. The venous blood is then again filled with oxygen in the lungs and returned back to the heart. The 2 are interconnected by small weblike vessels called capillaries. Peripheral vascular disease refers to any disease or disorder of the circulatory system outside of the brain and heart. Although the term peripheral vascular disease can include any disorder that affects any of the blood vessels, it often is used as a synonym for peripheral artery disease. Peripheral vascular disease is the most common disease of the arteries. It is caused by build-up of fatty material within the vessels, called atherosclerosis. Another name for this condition is arteriosclerosis, or hardening of the arteries. This is gradual process in which the artery gradually becomes blocked, narrowed, or weakened. When this condition affects the arteries of the heart, it is called coronary heart disease (coronary artery disease). Atherosclerosis is known for affecting the arteries of the heart (coronary arteries) and the brain (carotid arteries). Of the peripheral arteries, those of the legs are most often affected. Other arteries frequently affected by atherosclerosis include those supplying blood to the kidneys or arms.

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Sumatriptan, the active component of Sumavel DosePro, is a selective 5-hydroxy-tryptamine receptor subtype 1 (5-HT1) agonist. Sumatriptan delivered as the succinate salt is chemically designated as 3-[2-(dimethylamino)ethyl]-N-methyl-indole-5-methanesulfonamide succinate (1:1), and it has the following structure:The empirical formula is C14H21N3O2S &bull, C4H6O4, representing a molecular weight of 413.5. Sumavel DosePro is a 5-HT1B/1D receptor agonist (triptan) indicated for: 1.1 Acute Treatment of Migraine Attacks and Cluster Headache 1.2 Important Limitations 2 DOSAGE AND ADMINISTRATION 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 4.1 Intravenous Administration 4.2 Ischemic or Vasospastic Coronary Artery Disease 4.3 Cerebrovascular Syndromes 4.4 Peripheral Vascular Disease 4.5 Uncontrolled Hypertension 4.6 Do not use within 24 hours of treatment with Ergotamine-Containing or Ergot-Type Medications or Other 5-HT1 Agonists (e.g. triptans) 4.7 Hemiplegic or Basilar Migraine 4.8 Hypersensitivity 5 WARNINGS AND PRECAUTIONS 5.1 Risk of Myocardial Ischemia and Infarction and Other Adverse Cardiac Events 5.2 Sensations of Pain, Tightness, Pressure in the Chest and/or Throat, Neck and Jaw 5.3 Cerebrovascular Events and Fatalities 5.4 Other Vasospasm-Related Events, including Peripheral Vascular Ischemia and Colonic Ischemia 5.5 Serotonin Syndrome 5.6 Increase in Blood Pressure 5.7 Concomitant MAO-A inhibitors 5.8 Hypersensitivity 5.9 Seizures 5.10 Corneal Opacities 6 ADVERSE REACTIONS 6.1 Controlled Clinical Trials in Patients with Migraine Headache 6.2 Controlled Clinical Trials in Patients with Cluster Headache 6.3 Other Adverse Reactions Observed in Association with the Administration of Sumatriptan Injection 6.4 Other Adverse Reactions Observed in the Clinical Development of Sumatriptan 6.5 Clinical Studies Using Sumavel DosePro 6.6 Post-marketing Experience 7 DRUG INTERACTIONS 7.1 Monoamine Oxidase Inhibitors 7.2 5-HT1B/1D...


Peripheral Vascular Disease - American Heart Association

What is peripheral vascular disease? This refers to diseases of blood vessels outside the heart and brain. It's often a narrowing of vessels that carry ...


Peripheral vascular disease - Wikipedia, the free encyclopedia

Peripheral vascular disease (PVD), commonly referred to as peripheral arterial disease (PAD) or peripheral artery occlusive disease (PAOD), refers to the ...


Peripheral Vascular Disease (Peripheral Artery Disease) Causes ...

Mar 19, 2011 ... Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and brain. ...


Peripheral Vascular Disease: eMedicine Emergency Medicine

Mar 15, 2010 ... Overview: Peripheral vascular disease (PVD) is a nearly pandemic condition that has the potential to cause loss of limb or even loss of life ...


Peripheral Vascular Disease - Texas Heart Institute Heart ...

Peripheral vascular disease involves damage to or blockage in the blood vessels distant from your heart.

Peripheral Artery Disease

Peripheral arterial disease affects about 8 million Americans. It becomes more common as we get older. Read more about this condition. ...


Peripheral Arterial Disease Overview and Treatments - SIR

Interventional radiologists are vascular specialists who treat blocked arteries in the legs with medication, lifestyle changes or angioplasty.


Charcot-Marie-Tooth disease

Charcot-Marie-Tooth disease (CMT) is a term that describes a set of inherited conditions that cause damage to the periphery nerves (neuropathy).


Peripheral Arterial Disease, What Is

Peripheral arterial disease (P.A.D.) occurs when plaque (plak) builds up in the arteries that carry blood to your head, organs, and limbs. ...



Peripheral Vascular Disorders
Peripheral (per-IF-er-ull) vascular (VASS-q-ler) disorders (PVDs) are conditions that can change blood flow through blood vessels in your body. PVDs do not affect the blood vessels in your heart and brain. Disorders may be in your veins or arteries (R-ter-eez), or both. PVD may also be called peripheral arterial disease, or "PAD". PVD is a life-long condition that may get worse over time without treatment. If you have PVD, you are at a higher risk of having heart problems. Most people with PVD stay the same or get better without having surgery.

Peripheral arterial disease
Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. A substance made up of fat and cholesterol, called plaque, builds up on the walls of the arteries that supply blood to the arms and legs. The plaque causes the arteries to narrow or become blocked. This can reduce or stop blood flow, usually to the legs, causing them to hurt or feel numb. If severe enough, blocked blood flow can cause tissue death. If this condition is left untreated, a foot or leg may need to be amputated. A person with PAD also has an increased risk of heart attack, stroke and transient ischemic attack. You can often stop or reverse the buildup of plaque in the arteries with dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure.

Peripheral artery disease - legs
Peripheral artery disease is a condition of the blood vessels that leads to narrowing and hardening of the arteries that supply the legs and feet. This decreases blood flow, which can injure nerves and other tissues.

Peripheral artery disease
Peripheral artery disease, also known as peripheral arterial disease, is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs.

Vascular Diseases
The vascular system is the body's network of blood vessels. It includes the arteries, veins and capillaries that carry blood to and from the heart. Problems of the vascular system are common and can be serious. Arteries can become thick and stiff, a problem called arteriosclerosis. Blood clots can clog vessels and block blood flow to the heart or brain. Weakened blood vessels can burst, causing bleeding inside the body. You are more likely to have vascular disease as you get older. Other factors that make vascular disease more likely include

Duplex ultrasound
A duplex ultrasound is a test to see how blood moves through your arteries and veins.

Doppler ultrasound exam of an arm or leg
The test is done in the ultrasound or radiology department or in a peripheral vascular lab.

Animal studies indicate that dobutamine may be ineffective if the patient has recently received a ß-blocking drug. In such a case, the peripheral vascular resistance may increase.

Collagen vascular disease
Collagen is a tough, glue-like protein that makes up 30% of body protein. It shapes the structure of tendons, bones, and connective tissues. Problems with the immune system can affect these structures. This is known as collagen vascular disease. Collagen vascular diseases include: Dermatomyositis Polyarteritis nodosa Rheumatoid arthritis Scleroderma Systemic lupus erythematosus

Side effects associated with Brevital Sodium are extensions of pharmacologic effects and include: Cardiovascular —Circulatory depression, thrombophlebitis, hypotension, tachycardia, peripheral vascular collapse, and convulsions in association with cardiorespiratory arrest

Peripheral means "away from the center." It refers to the areas away from the center of the body or a body part. For example, the hands are peripheral to the shoulder. The toes are peripheral to the knees.