platelettransfusion

What is platelet transfusion?


Every year, nearly 5 million people in the United States receive life-saving blood transfusions. During a transfusion, you receive whole blood or parts of blood such as Some people worry about getting sick from giving or receiving blood. It is possible, but is very rare. The Food and Drug Administration and other organizations that collect blood make sure that blood is safe. Every single donation is tested for HIV/AIDS, Hepatitis C, syphilis and several other diseases that can be transmitted through blood. Some people who know they may need blood during surgery donate their own ahead of time. That is the safest type of transfusion.

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Regranex

REGRANEX Gel contains becaplermin, a recombinant human platelet-derived growth factor (rhPDGF-BB) for topical administration. Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet-derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds. Becaplermin Concentrate is produced by Novartis Vaccines and Diagnostics, Inc. and supplied to OMJ Pharmaceuticals under a shared manufacturing arrangement. REGRANEX Gel is a non-sterile, low bioburden, preserved, sodium carboxymethylcellulose-based (CMC) topical gel, containing the active ingredient becaplermin and the following inactive ingredients: sodium chloride, sodium acetate trihydrate, glacial acetic acid, water for injection, and methylparaben, propylparaben, and m-cresol as preservatives and l-lysine hydrochloride as a stabilizer. Each gram of REGRANEX Gel contains 100 &micro,g of becaplermin. REGRANEX (becaplermin) Gel is indicated for the treatment of lower extremity diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond and have an adequate blood supply. When used as an adjunct to, and not a substitute for, good ulcer care practices including initial sharp debridement, pressure relief and infection control, REGRANEX Gel increases the incidence of complete healing of diabetic ulcers.

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Thrombocytopenia

Thrombocyte is the medical term for platelet. Thrombocytopenia means a lower platelet count in the blood compared to the normal range. Thrombocytosis refers to a greater number of platelets compared to the normal range.

Plateletpheresis - Wikipedia, the free encyclopedia

Platelet transfusions are traditionally given to those undergoing chemotherapy for leukemia, multiple myeloma, those with aplastic anemia, AIDS, ...

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Low-Dose Platelet Transfusion May Increase Number of Transfusions ...

by L Barclay - 2010

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Platelet transfusions.

by DF Stroncek - 2007 - Cited by 57 - Related articles

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Clinical and laboratory aspects of platelet transfusion therapy

Aug 10, 2010 ... Platelets play a vital role in the maintenance of normal hemostatic activity. For patients with thrombocytopenia or impaired platelet ...

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Low-Dose Platelet Transfusions Deemed Safe - US News and World Report

Feb 17, 2010 ... Study finds no bleeding risk in practice that could stretch limited supplies.

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Platelet Transfusion in Acute Intracerebral Hemorrhage - Full Text ...

Jun 12, 2008 ... To prove the efficacy and safety of platelet transfusion for prevention of hematoma growth in patients who were stricken by acute ...

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Type 2 Heparin-induced Thrombocytopenia

Heparin-induced thrombocytopenia (throm-bo-seye-to-PEE-nee-ah) is a condition where there are too few platelets in the blood after receiving heparin. Heparin is a medicine that is usually used to prevent or treat a thrombosis (blood clot) or blood clotting disorder. Platelets are blood cells that help stop bleeding by sticking together to form a clot. Heparin-induced thrombocytopenia, also called HIT, may be mild (Type 1) or severe (Type 2). Type 1 HIT does not produce signs and symptoms, and is not due to a problem with the immune system. Type 2 HIT is due to an immune system problem, is often life-threatening, and needs immediate treatment. In Type 2 HIT, clots may form in blood vessels and cause serious problems in the heart, limbs, brain, and lungs. Usually in HIT, the platelet count (number of platelets) decreases 5 to 10 days after heparin was given. With rapid-onset HIT, the platelet count decreases within minutes to hours after receiving heparin. With delayed-onset HIT, a decrease in the platelet count may happen up to 100 days after heparin was given. Diagnosing and treating HIT as soon as possible may relieve symptoms and prevent serious, life-threatening complications.

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ReoPro

ReoPro Abciximab - Abciximab, ReoPro, is the Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation. Abciximab also binds to the vitronectin ((alpha) v(beta)3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.

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Contents

Blood transfusion
There are many reasons people receive blood transfusions, including surgery, injury, disease and illness. Blood has several components, including red cells, white cells, plasma and platelets. You'll receive a transfusion that provides the part or parts of blood that will be most helpful for you. Whole blood means the blood contains all its parts, but whole blood is rarely used for transfusion.

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Platelet aggregation test
The platelet aggregation test checks to see how well platelets, a part of blood, clump together and cause blood clotting.

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Platelet count
A platelet count is a test to measure how many platelets you have in your blood. Platelets help the blood clot. They are smaller than red or white blood cells.

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PLT
To diagnose a bleeding disorder or a bone marrow disease

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Blood Platelet Disorders
Platelets help wounds heal and prevent bleeding by forming blood clots. Your bone marrow makes platelets. Problems can result from having too few or too many platelets, or from platelets that do not work properly. If your blood has a low number of platelets, you can be at risk for mild to serious bleeding. If your blood has too many platelets, you may have a higher risk of blood clots. With other platelet disorders, the platelets do not work as they should. For example, in von Willebrand Disease, the platelets cannot stick together or cannot attach to blood vessel walls. This can cause excessive bleeding.

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pft
To help determine the cause of or potential for excessive bleeding, to monitor and evaluate platelet function, and to monitor the presence and effectiveness of antiplatelet medications

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Transfusion reaction - hemolytic
A hemolytic transfusion reaction is a serious problem that occurs after a patient receives a transfusion of blood. The red blood cells that were given to the patient are destroyed by the patient's own immune system.

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Platelet associated antibodies
A test for platelet-associated antibodies shows whether you have antibodies that are directed against platelets in your blood.

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Lipoprotein-associated phospholipase A2
To help determine your risk of cardiovascular disease (CVD), coronary heart disease (CHD), and your risk of having an ischemic stroke

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Becaplermin
Becaplermin is used to treat skin ulcers, usually on the lower leg, in patients with type 2 diabetes mellitus. It works by stimulating the wound to heal. It is important to use other methods for good skin ulcer care when using becaplermin.

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Congenital platelet function defects
Congenital platelet function defects are problems with platelets, one of the blood elements needed for normal blood clotting. Congenital means present from birth.

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