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What is Prilosec?
Omeprazole is used to treat certain conditions in which there is too much acid in the stomach. It is used to treat gastric and duodenal ulcers and gastroesophageal reflux disease (GERD), a condition in which the acid in the stomach washes back up into the esophagus. Sometimes omeprazole is used in combination with antibiotics to treat ulcers associated with infection caused by the H. pylori bacteria (germ).
Read more on www.mayoclinic.com
Also known as Nexium, Omeprazole, Esomeprazole, omeprazole magnesium, H 168-68, H 168 68, H 16868
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Prilosec information from trusted sources:
Prilosec
The active ingredient in PRILOSEC (omeprazole) Delayed-Release Capsules is a substituted benzimidazole, 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl]-1H-benzimidazole, a compound that inhibits gastric acid secretion. Its empirical formula is C17H19N3O3S, with a molecular weight of 345.42. The structural formula is:Omeprazole is a white to off-white crystalline powder that melts with decomposition at about 155°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of omeprazole is a function of pH, it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. PRILOSEC is a proton pump inhibitor indicated for: 1.1 Duodenal Ulcer (adults) 1.2 Gastric Ulcer (adults) 1.3 Treatment of Gastroesophageal Reflux Disease (GERD) (adults and pediatric patients) 1.4 Maintenance of Healing of Erosive Esophagitis (adults and pediatric patients) 1.5 Pathological Hypersecretory Conditions (adults) 2 DOSAGE AND ADMINISTRATION 2.1 Short-Term Treatment of Active Duodenal Ulcer 2.2 H. pylori Eradication for the Reduction of the Risk of Duodenal Ulcer Recurrence 2.3 Gastric Ulcer 2.4 Gastroesophageal Reflux Disease (GERD) 2.5 Maintenance of Healing of Erosive Esophagitis 2.6 Pathological Hypersecretory Conditions 2.7 Pediatric Patients 2.8 Alternative Administration Options 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 5. WARNINGS AND PRECAUTIONS 5.1 Concomitant Gastric Malignancy 5.2 Atrophic Gastritis 5.3 Combiniation Use of PRILOSEC with Amoxicillin 5.4 Combination Use of PRILOSEC with Clarithromycin 6 ADVERSE REACTIONS 6.1 Clinical Trials Experience with PRILOSEC Monotherapy 6.2 Clinical Trials Experience with PRILOSEC in Combination Therapy for H. pylori Eradication 6.3 Post-marketing Experience 7 DRUG INTERACTIONS 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.3 Nursing Mothers 8.4 Pediatric Use 8.5 Geriatric Use 8.6... Read more on
dailymed.nlm.nih.gov
Prilosec
The active ingredient in PRILOSEC (omeprazole) Delayed-Release Capsules is a substituted benzimidazole, 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl]-1Hbenzimidazole, a compound that inhibits gastric acid secretion. Read more on
www.druglib.com
Omeprazole
Omeprazole is used to treat certain conditions in which there is too much acid in the stomach. It is used to treat gastric and duodenal ulcers and gastroesophageal reflux disease (GERD), a condition in which the acid in the stomach washes back up into the esophagus. Sometimes omeprazole is used in combination with antibiotics to treat ulcers associated with infection caused by the H. pylori bacteria (germ). Read more on
www.mayoclinic.com
Prilosec
Prilosec is prescribed for the short-term treatment (4 to 8 weeks) of the following: Read more on
www.pdrhealth.com
Nexium
National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Fifth Edition: Approved Standard NCCLS Document M7-A5, Vol. 20, no. 2, NCCLS, Wayne, PA, January 2000. Read more on
www.druglib.com
Contents
Description and Clinical Pharmacology
The active ingredient in PRILOSEC (omeprazole) Delayed-Release Capsules is a substituted benzimidazole, 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl]-1 H -benzimidazole, a compound that inhibits gastric acid secretion. Its empirical formula is C17H19N3O3S, with a molecular weight of 345.42. The structural formula is: Omeprazole is a white to off-white crystalline powder that melts with decomposition at about 155°C. It is a weak base, freely soluble in ethanol and...
Read more on
www.druglib.com
Drug Interactions, Overdosage and Contraindications
Reports have been received of overdosage with omeprazole in humans. Doses ranged up to 2400 mg (120 times the usual recommended clinical dose). Manifestations were variable, but included confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, diaphoresis, flushing, headache, dry mouth, and other adverse reactions similar to those seen in normal clinical experience. [ See Adverse Reactions (6) ] Symptoms were transient, and no serious clinical outcome has been reported when PRILOSEC...
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www.druglib.com
Indications and Dosage
PRILOSEC is indicated for short-term treatment of active duodenal ulcer in adults. Most patients heal within four weeks. Some patients may require an additional four weeks of therapy.
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www.druglib.com
Other Rx Information
1. National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically -Fifth Edition. Approved Standard NCCLS Document M7-A5, Vol, 20, No. 2, NCCLS, Wayne, PA, January 2000.
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www.druglib.com
Precautions
It is important that your doctor check your progress at regular visits. If your condition does not improve, or if it becomes worse, check with your doctor .
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www.mayoclinic.com
Proper Use
Take omeprazole capsules or delayed-release capsules before a meal, preferably in the morning. Omeprazole tablets may be taken with food or on an empty stomach. Take omeprazole powder for oral suspension on an empty stomach at least 1 hour before a meal. For patients receiving continuous feeding through a tube, feeding should be temporarily stopped about 3 hours before and 1 hour after administration of omeprazole powder for oral suspension.
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www.mayoclinic.com
Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
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www.mayoclinic.com
Summary
The active ingredient in PRILOSEC (omeprazole) Delayed-Release Capsules is a substituted benzimidazole, 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl]-1Hbenzimidazole, a compound that inhibits gastric acid secretion.
Read more on
www.druglib.com