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Avodart
AVODART is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5α-reductase, an intracellular enzyme that converts testosterone to DHT. AVODART, a 5α-reductase inhibitor, is indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to: (1.1) 1.1 Monotherapy 1.2 Combination With Alpha-Blocker 2 DOSAGE AND ADMINISTRATION 2.1 Monotherapy 2.2 Combination With Alpha-Blocker 2.3 Dosage Adjustment in Specific Populations 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 5 WARNINGS AND PRECAUTIONS 5.1 Exposure of WomenRisk to Male Fetus 5.2 Evaluation for Other Urological Diseases 5.3 Effects on Prostate-Specific Antigen (PSA) and the Use of PSA in Prostate Cancer Detection 5.4 Blood Donation 5.5 Effect on Semen Characteristics 6 ADVERSE REACTIONS 6.1 Clinical Trials Experience 6.2 Postmarketing Experience 7 DRUG INTERACTIONS 7.1 Cytochrome P450 3A Inhibitors 7.2 Alpha-Adrenergic Blocking Agents 7.3 Calcium Channel Antagonists 7.4 Cholestyramine 7.5 Digoxin 7.6 Warfarin 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.3 Nursing Mothers 8.4 Pediatric Use 8.5 Geriatric Use 8.6 Renal Impairment 8.7 Hepatic Impairment 10 OVERDOSAGE 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action 12.2 Pharmacodynamics 12.3 Pharmacokinetics 13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility 13.2 Animal Toxicology 13.3 Reproductive and Developmental Toxicity 14 CLINICAL STUDIES 14.1 Monotherapy 14.2 Combination With Alpha-Blocker Therapy (CombAT) 16 HOW SUPPLIED/STORAGE AND HANDLING 17 PATIENT COUNSELING INFORMATION 17.1 Exposure of WomenRisk to Male Fetus 17.2 Blood Donation Patient Information Principal Display Panel FULL PRESCRIBING INFORMATION...
PSA Velocity - What is PSA Velocity
PSA (prostate specific antigen) velocity refers to the speed of change of PSA over time. More and more evidence has been found that PSA velocity is an ...
PSA Velocity Most Significant Predictor of Prostate Cancer Mortality
May 29, 2007 ... The most significant single predictor of mortality that is prostate cancer–specific is an elevated rate of increase in pretreatment levels ...
PSA Velocity May be Irrelevant in Detection of Prostate Cancer
Sep 18, 2009 ... Measuring velocity of prostate cancer specific antigen rise over time may not be necessary before deciding whether a man needs a prostate ...
PSA Velocity: What Does a Quick Rise in PSA Mean? - Prostate
Feb 19, 2008 ... My friend ,who is in his early 50s, just got the results of his annual PSA test - it was between 4-5. The results of his previous 6 annual ...
PSA Velocity Quiz - Health Quizzes - Urology Channel
May 29, 2008 ... PSA naturally rises as a man ages, but a steady rise can indicate the presence of cancer. This quiz looks at the rate of PSA change over ...
Pretreatment PSA velocity and risk of death from prostate cancer ...
by AV D'Amico - 2005 - Cited by 182 - Related articles
Understanding Prostate Changes - National Cancer Institute
Jump to What do PSA results mean?: Your doctor may monitor your PSA velocity, which means the rate of change in your PSA level over time. ...
Prostate Cancer and PSA Velocity: Caution Ahead
Nov 8, 2006 ... If the PSA velocity was 1, then the risk of death from prostate cancer was increased about 4 times. For example, if the PSA test one year ...
Need More Than PSA Velocity Before Biopsy
Feb 24, 2011 ... One test that doctors use for screening is called PSA velocity, which is actually an analysis of a series of tests - it is looking at the ...