serotoninsyndrome

What is serotonin syndrome?


Serotonin syndrome most often occurs when two drugs that affect the body's level of serotonin are taken together at the same time. The drugs cause too much serotonin to be released or to remain in the brain area.

Read more on www.nlm.nih.gov
Also known as hyperserotonemia, serotonergic syndrome, Serotonin Syndromes
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Serotonin syndrome

Serotonin syndrome is a potentialyl life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by nerve cells.

Read more on www.nlm.nih.gov

Serotonin syndrome

Serotonin syndrome occurs when you take medications that cause high levels of the chemical serotonin to accumulate in your body. It can occur when you increase the dose of such a drug or add a new drug to the ones you take already. Certain illicit drugs and dietary supplements also can cause serotonin syndrome.

Read more on www.mayoclinic.com

5-Hydroxy Tryptamine

To help diagnose a serotonin-secreting carcinoid tumor

Read more on www.labtestsonline.org

SSRIs

In the treatment of depression, selective serotonin reuptake inhibitors (SSRIs) increase the level in the brain of a substance called serotonin.

Read more on www.nhs.uk

Selective serotonin reuptake inhibitors

Clinical depression is not just grief or sadness. It is an illness that can challenge the person's ability to perform even routine daily activities. At its worst, depression may lead the person to contemplate or commit suicide. Depression represents a burden for the person and his or her family. Sometimes that burden can seem overwhelming. Several different types of mood disorders exist.

Effexor XR

Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding. Altered anticoagulant effects, including increased bleeding, have been reported when SSRIs and SNRIs are...

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Serotonin syndrome - Wikipedia, the free encyclopedia

Serotonin syndrome is a potentially life-threatening adverse drug reaction that may occur following therapeutic drug use, inadvertent interactions between ...

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What is Serotonin Syndrome?

Jul 26, 2006 ... Serotonin Syndrome is a potentially life-threatening condition that is caused by elevated serotonin concentrations in the body.

Read more on bipolar.about.com

Pediatric Selective Serotonin Reuptake Inhibitor Toxicity ...

Apr 15, 2010 ... Serotonin syndrome, characterized by mental status changes, neuromuscular dysfunction, and autonomic instability, is thought to be secondary ...

Read more on emedicine.medscape.com

Serotonin Syndrome

Feb 19, 2009 ... A description of the causes, symptoms and treatment of serotonin syndrome, a dangerous buildup of serotonin in the central nervous system.

Read more on depression.about.com

Contents

Complications
Serotonin syndrome generally doesn't cause any problems once serotonin levels are back to normal. But if left untreated, severe serotonin syndrome can lead to unconsciousness and death.

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Exams and Tests
The diagnosis is usually made by asking questions about your medical history, including the types of drugs you take.

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Medical advice
Call your health care provider right away if you have symptoms of serotonin syndrome.

Read more on www.nlm.nih.gov
Outlook (Prognosis)
Patients may get slowly worse and can become severely ill if not quickly treated. Untreated serotonin syndrome can be deadly. However, with treatment, symptoms can usually go away in less than 24 hours.

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Possible Complications
Uncontrolled muscle spasms can cause severe muscle breakdown. The products produced when the muscles break down are released into your blood and eventually go through the kidneys. This can cause severe kidney damage if not recognized and treated appropriately. With appropriate treatment, the condition is reversible.

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Preparing for your appointment
Because serotonin syndrome can be a life-threatening condition, seek emergency treatment right away if you have worsening or severe symptoms.

Read more on www.mayoclinic.com
Prevention
Always tell all of your healthcare providers what medicines you take. Patients who take triptans with SSRIs or SNRIs should be closely followed, especially right after starting a medicine or increasing its dosage.

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Risk factors
Some people are more susceptible to the drugs and supplements that cause serotonin syndrome than are others, but the condition can occur in anyone.

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Symptoms
Symptoms occur within minutes to hours, and may include:Agitation or restlessness; Diarrhea; Fast heart beat; Hallucinations; Increased body temperature; Loss of coordination; Nausea; Overactive reflexes; Rapid changes in blood pressure; Vomiting

Read more on www.nlm.nih.gov
Tests and diagnosis
No single test can confirm a serotonin syndrome diagnosis. Your doctor will diagnose the condition by ruling out other possibilities.

Read more on www.mayoclinic.com
Treatments and drugs
Treatment of serotonin syndrome depends on the severity of your symptoms.

Read more on www.mayoclinic.com