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What is simvastatin (zocor)?
ZOCOR (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. This is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzymeA (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting step in the biosynthesis of cholesterol.
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simvastatin (zocor) information from trusted sources:
Simvastatin
Simvastatin is used together with a proper diet to treat high cholesterol levels in the blood. Using this medicine may help prevent medical problems caused by such substances clogging the blood vessels. This medicine may also be used to prevent certain types of heart problems in patients with risk factors for heart problems . Read more on
www.mayoclinic.com
simcor
SIMCOR tablets contain niacin extended-release (NIASPAN) and simvastatin in combination. Simvastatin, an inhibitor of HMG-CoA reductase, and niacin are both lipid-altering agents. SIMCOR is a combination of simvastatin, an HMG-Co-A reductase inhibitor, and extended-release niacin (Niaspan), nicotinic acid. SIMCOR is indicated to: 1.1 Patients with Hypercholesterolemia Requiring Modifications of Lipid Profiles 2 DOSAGE AND ADMINISTRATION 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 5 WARNINGS AND PRECAUTIONS 5.1 Myopathy/Rhabdomyolysis 5.2 Liver Dysfunction 5.3 Laboratory Abnormalities 6 ADVERSE REACTIONS 6.1 Clinical Studies Experience 7 DRUG INTERACTIONS 7.1 CYP3A4 Inhibitors 7.2 Cyclosporine or Danazol 7.3 Amiodarone or Verapamil 7.4 Gemfibrozil and other Fibrates 7.5 Propranolol 7.6 Digoxin 7.7 Coumarin Anticoagulants 7.8 Aspirin 7.9 Antihypertensive Therapy 7.10 Bile Acid Sequestrants 7.11 Other 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.3 Nursing Mothers 8.4 Pediatric Use 8.5 Geriatric Use 8.6 Gender 8.7 Renal Impairment 8.8 Hepatic Impairment 10 OVERDOSAGE 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action 12.2 Pharmacodynamics 12.3 Pharmacokinetics 13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility 13.2 Animal Toxicology and/or Pharmacology 14 CLINICAL STUDIES 14.1 Modifications of Lipid Profiles 16 HOW SUPPLIED/STORAGE AND HANDLING 17 PATIENT COUNSELING INFORMATION 17.1 Dosing Time 17.2 Tablet Integrity 17.3 Dosing Interruption 17.4 Muscle Pain 17.5 Flushing 17.6 Use of Aspirin or other Non-Inflammatory Medication 17.7 Diet 17.8 Supplements 17.9 Dizziness 17.10 Diabetics 17.11 Pregnancy 17.12 Breastfeeding FULL PRESCRIBING INFORMATION... Read more on
dailymed.nlm.nih.gov
Contents
Zocor
Zocor is a cholesterol-lowering drug. Your doctor may prescribe Zocor in addition to a cholesterol-lowering diet if your blood cholesterol level is too high, and if you have been unable to lower it by diet alone. For people at high risk of heart disease, current guidelines call for considering drug therapy when LDL levels reach 130. For people at lower risk, the cut-off is 160. For those at little or no risk, it's 190.
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www.pdrhealth.com
Simvastatin
ZOCOR1 (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding (beta)-hydroxyacid form. This is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting step in the biosynthesis of cholesterol.
Read more on
www.druglib.com
simcor
SIMCOR tablets contain niacin extended-release (NIASPAN) and simvastatin in combination. Simvastatin, an inhibitor of HMG-CoA reductase, and niacin are both lipid-altering agents. Niacin Extended-Release is an extended release form of nicotinic acid, or 3-pyridinecarboxylic acid.
Read more on
www.druglib.com
SIMVASTATIN - ORAL (Zocor) side effects, medical uses, and drug ...
Mar 12, 2011 ... Consumer information about the medication SIMVASTATIN - ORAL (Zocor), includes side effects, drug interactions, recommended dosages, ...
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www.medicinenet.com
Zocor (Simvastatin) - Drug InfoNet - Newsfeed - [general]
Patient information including contraindications, side effects, warnings and precautions.
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www.druginfonet.com
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Vytorin
VYTORIN contains ezetimibe, a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor.
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www.druglib.com
Colesevelam
Colesevelam is used along with diet, weight loss, and exerciseto reduce the amount of cholesterol and certain fatty substances in the blood. Colesevelam may be used alone or in combination with other cholesterol-lowering medications known as statins (atorvastatin [Lipitor], cerivastatin [Baycol], lovastatin [Mevacor], pravastatin [Pravachol], or simvastatin [Zocor]). Colesevelam is also used to control blood sugar levels in patients with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Colesevelam is in a class of medications called bile acid sequestrants. It works by binding bile acids in your intestines to form a product that is removed from the body.
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www.nlm.nih.gov